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http://hdl.handle.net/2445/192910
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DC Field | Value | Language |
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dc.contributor.author | Gomila, Alexandre M. J. | - |
dc.contributor.author | Pérez-Mejías, Gonzalo | - |
dc.contributor.author | Nin-Hill, Alba | - |
dc.contributor.author | Guerra-Castellano, Alejandra | - |
dc.contributor.author | Casas-Ferrer, Laura | - |
dc.contributor.author | Ortiz Tescari, Sthefany | - |
dc.contributor.author | Díaz Quintana, Antonio | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.contributor.author | Rovira i Virgili, Carme | - |
dc.contributor.author | De la Rosa, Miguel A. | - |
dc.contributor.author | Díaz Moreno, Irene | - |
dc.contributor.author | Gorostiza, Pau | - |
dc.contributor.author | Giannotti, Marina I. | - |
dc.contributor.author | Lagunas, Anna | - |
dc.date.accessioned | 2023-02-01T12:46:02Z | - |
dc.date.available | 2023-02-01T12:46:02Z | - |
dc.date.issued | 2022-11-19 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192910 | - |
dc.description.abstract | It has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the cytochrome bc1 can proceed at long-distance through the aqueous solution. Cytochrome c is thought to adjust its activity by changing the affinity for its partners via Tyr48 phosphorylation, but it is unknown how it impacts the nanoscopic environment, interaction forces, and long-range electron transfer. Here, we constrain the orientation and separation between cytochrome c1 and cytochrome c or the phosphomimetic Y48pCMF cytochrome c, and deploy an array of single-molecule, bulk, and computational methods to investigate the molecular mechanism of electron transfer regulation by cytochrome c phosphorylation. We demonstrate that phosphorylation impairs long-range electron transfer, shortens the long-distance charge conduit between the partners, strengthens their interaction, and departs it from equilibrium. These results unveil a nanoscopic view of the interaction between redox protein partners in electron transport chains and its mechanisms of regulation. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-022-34809-1 | - |
dc.relation.ispartof | Nature Communications, 2022, vol. 13, p. 7100 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-022-34809-1 | - |
dc.rights | cc-by (c) Gomila, Alexandre M. J. et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciència dels Materials i Química Física) | - |
dc.subject.classification | Química bioinorgànica | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Bioinorganic chemistry | - |
dc.subject.other | Proteins | - |
dc.title | Phosphorylation disrupts long-distance electron transport in cytochrome c | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 727184 | - |
dc.date.updated | 2023-02-01T12:46:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciència dels Materials i Química Física) |
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File | Description | Size | Format | |
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727184.pdf | 3.42 MB | Adobe PDF | View/Open |
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