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http://hdl.handle.net/2445/192982
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DC Field | Value | Language |
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dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Ponomarenko, Julia | - |
dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Hereu, Mercè | - |
dc.contributor.author | Miralles Pérez, Bernat | - |
dc.contributor.author | Romeu Ferran, Marta | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.date.accessioned | 2023-02-02T08:58:05Z | - |
dc.date.available | 2023-02-02T08:58:05Z | - |
dc.date.issued | 2022-11-03 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192982 | - |
dc.description.abstract | The goal of this work is to explore if the changes induced by D-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with D-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake D-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, D-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu14214656 | - |
dc.relation.ispartof | Nutrients, 2022, vol. 14, num. 21, p. 4656 | - |
dc.relation.uri | https://doi.org/10.3390/nu14214656 | - |
dc.rights | cc-by (c) Ramos Romero, Sara et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Pes corporal | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Body weight | - |
dc.title | Fiber-like Action of D-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 727471 | - |
dc.date.updated | 2023-02-02T08:58:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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727471.pdf | 1.66 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License