1. Dipòsit Digital de la Universitat de Barcelona
  2. Recerca
  3. Bioquímica i Biomedicina Molecular
  4. Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/193026
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGinex, Tiziana-
dc.contributor.authorMarco-Marín, Clara-
dc.contributor.authorWieczor, Miłosz-
dc.contributor.authorMata, Carlos P.-
dc.contributor.authorKrieger, James-
dc.contributor.authorRuiz-Rodriguez, Paula-
dc.contributor.authorLópez-Redondo, Maria Luisa-
dc.contributor.authorFrancésc-Gómez, Clara-
dc.contributor.authorMelero, Roberta-
dc.contributor.authorSánchez-Sorzano, Carlos Oscar-
dc.contributor.authorMartínez, Marta-
dc.contributor.authorGougeard, Nadine-
dc.contributor.authorForcada-Nadal, Alicia-
dc.contributor.authorZamora-Caballero, Sara-
dc.contributor.authorGozalbo-Rovira, Roberto-
dc.contributor.authorSanz-Frasquet, Carla-
dc.contributor.authorArranz, Rocío-
dc.contributor.authorBravo, Jeronimo-
dc.contributor.authorRubio, Vicente-
dc.contributor.authorMarina, Alberto-
dc.contributor.authorGeller, Ron-
dc.contributor.authorComas, Iñaki-
dc.contributor.authorGil, Carmen-
dc.contributor.authorCoscolla, Mireia-
dc.contributor.authorOrozco López, Modesto-
dc.contributor.authorLlácer, José Luis-
dc.contributor.authorCarazo, Jose-Maria-
dc.date.accessioned2023-02-03T10:33:43Z-
dc.date.available2023-02-03T10:33:43Z-
dc.date.issued2022-07-11-
dc.identifier.issn1553-7366-
dc.identifier.urihttp://hdl.handle.net/2445/193026-
dc.description.abstractThe S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness-
dc.format.extent28 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631-
dc.relation.ispartofPLoS Pathogens, 2022, vol. 18, num. 7-
dc.relation.urihttps://doi.org/10.1371/journal.ppat.1010631-
dc.rightscc-by (c) Ginex, Tiziana et al., 2022-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)-
dc.subject.classificationSARS-CoV-2-
dc.subject.classificationInfeccions-
dc.subject.classificationMutació (Biologia)-
dc.subject.classificationVacunes-
dc.subject.otherSARS-CoV-2-
dc.subject.otherInfections-
dc.subject.otherMutation (Biology)-
dc.subject.otherVaccines-
dc.titleThe estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec724866-
dc.date.updated2023-02-03T10:33:43Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
724866.pdf4.07 MBAdobe PDFView/Open
Show simple item record


This item is licensed under a Creative Commons License Creative Commons