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Title: | Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium |
Author: | Pastorino, Roberta Sassano, Michele Danilo Tiziano, Francesco Giraldi, Luca Amore, Rosarita Arzani, Dario Abiusi, Emanuela Ahrens, Wolfgang Alemany Vilches, Laia Canova, Cristina Healy, Claire Mary Holcatova, Ivana Lagiou, Pagona Polesel, Jerry Popovic, Maja Nygård, Ståle Cadoni, Gabriella Znaor, Ariana Boffetta, Paolo Matsuo, Keitaro Oze, Isao Brennan, Paul Boccia, Stefania |
Keywords: | Càncer de coll Càncer de cap Marcadors bioquímics Expressió gènica Neck cancer Head cancer Biochemical markers Gene expression |
Issue Date: | 20-Sep-2022 |
Publisher: | American Association for Cancer Research (AACR) |
Abstract: | Background: Identification of screening tests for the detection of head and neck cancer (HNC) at an early stage is an important strategy to improving prognosis. Our objective was to identify plasma circulating miRNAs for the diagnosis of HNC (oral and laryngeal subsites), within a multicenter International Head and Neck Cancer Epidemiology consortium. Methods: A high-throughput screening phase with 754 miRNAs was performed in plasma samples of 88 cases and 88 controls, followed by a validation phase of the differentially expressed miRNAs, identified in the screening, in samples of 396 cases and 396 controls. Comparison of the fold changes (FC) was carried out using the Wilcoxon rank-sum test and the Dunn multiple comparison test. Results: We identified miR-151-3p (FC = 1.73, P = 0.007) as differentially expressed miRNAs in the screening and validation phase. The miR-151-3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls. Conclusions: We identified miR-151-3p as an early marker of HNC. This miRNA was the only upregulated in patients at early stages of the disease, independently of the smoking status. Impact: The prognosis for HNC is still poor. The discovery of a new diagnostic biomarker could lead to an earlier tumor discovery and therefore to an improvement in patient prognosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1158/1055-9965.EPI-22-0376 |
It is part of: | Cancer Epidemiology, Biomarkers & Prevention, 2022, vol. 31, num. 12, p. 2237-2243 |
URI: | http://hdl.handle.net/2445/193112 |
Related resource: | https://doi.org/10.1158/1055-9965.EPI-22-0376 |
ISSN: | 1538-7755 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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