Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/193139
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Flood, Brian | - |
dc.contributor.author | Manils Pacheco, Joan | - |
dc.contributor.author | Nulty, Ciara | - |
dc.contributor.author | Flis, Ewelina | - |
dc.contributor.author | Kenealy, Sinead | - |
dc.contributor.author | Barber, Gillian | - |
dc.contributor.author | Fay, Joanna | - |
dc.contributor.author | H.G. Mills, Kingston | - |
dc.contributor.author | Kay, Elaine W. | - |
dc.contributor.author | Creagh, Emma M. | - |
dc.date.accessioned | 2023-02-06T15:28:01Z | - |
dc.date.available | 2023-02-06T15:28:01Z | - |
dc.date.issued | 2019-04-04 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | http://hdl.handle.net/2445/193139 | - |
dc.description.abstract | Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the production of the proinflammatory cytokines IL-1β and IL-18, and has a key role in pyroptotic cell death. We have previously demonstrated a protective role for caspase-11 during dextran sulphate sodium (DSS)-induced colitis, however the importance of caspase-11 during colorectal tumour development remains unclear. Here, we show that Casp11−/− mice are highly susceptible to the azoxymethane (AOM)-DSS model of colitis-associated cancer (CAC), compared to their wild type (WT) littermates. We show that deficient IL-18 production occurs at initial inflammation stages of disease, and that IL-1β production is more significantly impaired in Casp11−/− colons during established CAC. We identify defective STAT1 activation in Casp11−/− colons during disease progression, and show that IL-1β signalling induces caspase-11 expression and STAT1 activation in primary murine macrophages and intestinal epithelial cells. These findings uncover an anti-tumour role for the caspase-11 and the non-canonical inflammasome during CAC, and suggest a critical role for caspase-11, linking IL-1β and STAT1 signalling pathways. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Macmillan Publishers | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41388-018-0613-5 | - |
dc.relation.ispartof | Oncogene, 2019, vol. 38, num. 14, p. 2658-2674 | - |
dc.relation.uri | https://doi.org/10.1038/s41388-018-0613-5 | - |
dc.rights | cc by (c) Flood, Brian et al., 2019 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Carcinogènesi | - |
dc.subject.classification | Colitis | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.other | Carcinogenesis | - |
dc.subject.other | Colitis | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Colorectal cancer | - |
dc.title | Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 723846 | - |
dc.date.updated | 2023-02-06T15:28:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30538296 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
723846.pdf | 6.52 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License