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Title: Long-term strenuous exercise promotes vascular injury by selectively damaging the tunica media: experimental evidence
Author: Rubies, Cira
Batlle, Montserrat
Sanz de la Garza, María
Dantas, Ana Paula
Jorba, Ignasi
Fernandez, Guerau
Sangüesa Puigventós, Gemma
Abuli, Marc
Brugada Terradellas, Josep, 1958-
Sitges Carreño, Marta
Navajas Navarro, Daniel
Mont Girbau, Lluís
Guasch i Casany, Eduard
Keywords: Esports extrems
Malalties vasculars
Malalties coronàries
Cèl·lules musculars
Extreme sports
Vascular diseases
Coronary diseases
Muscle cells
Issue Date: 13-Jul-2022
Abstract: Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise.
Note: Reproducció del document de
It is part of: Jacc-Basic To Translational Science, 2022, vol. 7, num. 7, p. 681-693
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ISSN: 2452-302X
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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