Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/193360
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Battram, Anthony M. | - |
dc.contributor.author | Oliver Caldés, Aina | - |
dc.contributor.author | Suárez-Lledó, María | - |
dc.contributor.author | Lozano, Miquel | - |
dc.contributor.author | Bosch i Crespo, Miquel | - |
dc.contributor.author | Martínez Cibrian, Nuria | - |
dc.contributor.author | Cid Vidal, Joan | - |
dc.contributor.author | Moreno, David F. | - |
dc.contributor.author | Rodríguez Lobato, Luis Gerardo | - |
dc.contributor.author | Urbano Ispizua, Álvaro | - |
dc.contributor.author | Fernández de Larrea Rodríguez, Carlos José | - |
dc.date.accessioned | 2023-02-09T14:11:30Z | - |
dc.date.available | 2023-02-09T14:11:30Z | - |
dc.date.issued | 2022-06-22 | - |
dc.identifier.issn | 2329-0501 | - |
dc.identifier.uri | http://hdl.handle.net/2445/193360 | - |
dc.description.abstract | Autologous cell immunotherapy using B cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells is an effective novel treatment for multiple myeloma (MM). This therapy has only been used for relapsed and refractory patients, at which stage the endogenous T cells used to produce the CAR-T cells are affected by the immunosuppressive nature of advanced MM and/or side effects of previous therapies. An alternative pool of fitter T cells is found in leukocytoapheresis products that are routinely collected to obtain hematopoietic progenitor cells for autologous stem cell transplantation (ASCT) early in the treatment of MM. However, to mobilize the progenitor cells, patients are dosed with granulocyte colony-stimulating factor (G-CSF), which is reported to adversely affect T cell proliferation, function, and differentiation. Here, we aimed to first establish whether G-CSF treatment negatively influences T cell phenotype and to ascertain whether previous exposure of T cells to G-CSF is deleterious for anti-BCMA CAR-T cells. We observed that G-CSF had a minimal impact on T cell phenotype when added in vitro or administered to patients. Moreover, we found that CAR-T cell fitness and anti-tumor activity were unaffected when generated from G-CSF-exposed T cells. Overall, we showed that ASCT apheresis products are a suitable source of T cells for anti-BCMA CAR-T cell manufacture. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cell Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.omtm.2022.06.010 | - |
dc.relation.ispartof | Molecular Therapy-Methods & Clinical Development, 2022, vol. 26, p. 207-223 | - |
dc.relation.uri | https://doi.org/10.1016/j.omtm.2022.06.010 | - |
dc.rights | cc-by (c) Battram, Anthony M. et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Teràpia cel·lular | - |
dc.subject.classification | Mieloma múltiple | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | T cells | - |
dc.subject.other | Cellular therapy | - |
dc.subject.other | Multiple myeloma | - |
dc.subject.other | Gene expression | - |
dc.title | T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729419 | - |
dc.date.updated | 2023-02-09T14:11:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9325404 | - |
dc.identifier.pmid | 35859694 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
729419.pdf | 2.18 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License