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Title: Melanogenesis and hypopigmentation: the case of vitiligo
Author: Vinardell Martínez-Hidalgo, Ma. Pilar
Solange Maddaleno, Adriana
Mitjans Arnal, Montserrat
Keywords: Melanina
Malalties de la pell
Skin diseases
Issue Date: 29-Dec-2022
Publisher: Wolters Kluwer - Medknow
Abstract: Melanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair and eyes. The process of synthesis of melanin is called melanogenesis and is regulated by various mechanisms and factors such as genetic, environmental and endocrine factors. The knowledge of the pigmentation process is important to understand hypopigmentation disorders such as vitiligo and also to design adequate treatments. In the present work, we review the signalling pathways involved in vitiligo. Finally, current therapies and treatments including topical, oral and phototherapies are discussed and described, emphasizing future therapies based on different pigmentation mechanisms.
Note: Reproducció del document publicat a: http://year=2022;
It is part of: Indian Journal of Dermatology, 2022, vol. 67, num. 5, p. 524-530
ISSN: 0019-5154
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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