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Title: | Cortical thinning over two years after first-episode psychosis depends on age of onset |
Author: | Pina Camacho, Laura Martinez, Kenia Díaz Caneja, Covadonga M. Mezquida Mateos, Gisela Cuesta, Manuel J. Moreno, Carmen (Moreno Koch) Amoretti Guadall, Silvia González-Pinto, Ana Arango, Celso Vieta i Pascual, Eduard, 1963- Castro Fornieles, Josefina Lobo, Antonio Fraguas, David Bernardo Arroyo, Miquel Janssen, Joost Parellada, Mara PEPs Group |
Keywords: | Psicosi Cervell Escorça cerebral Lòbul frontal Lòbul temporal Edat Psychoses Brain Cerebral cortex Frontal lobe Temporal lobe Age |
Issue Date: | 11-Mar-2022 |
Abstract: | First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15-35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. |
Note: | Reproducció del document publicat a https://doi.org/10.1038/s41537-021-00196-7 |
It is part of: | Schizophrenia, 2022, vol. 8, num. 1, p. 20 |
URI: | https://hdl.handle.net/2445/193844 |
Related resource: | https://doi.org/10.1038/s41537-021-00196-7 |
ISSN: | 2754-6993 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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