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Title: Galectins-1, -3 and -9 Are Present in Breast Milk and Have a Role in Early Life Development
Author: Rio-Aige, Karla
Girbal, Marina
Selma-Royo, Marta
Parra-Llorca, Anna
González, Sonia
Martínez Costa, Cecilia
Castell, Margarida
Collado, Maria Carmen
Pérez-Cano, Francisco J.
Rodríguez Lagunas, María José
Keywords: Llet materna
Cordó umbilical
Breast milk
Umbilical cord
Issue Date: 1-Oct-2022
Publisher: MDPI
Abstract: Galectins (Gal) are a family of conserved soluble proteins with high affinity for β-galactoside structures. They have been recognized as important proteins for successful pregnancy. However, little is known about their presence in breast milk and their role in early infancy. Gal-1, -3 and -9 concentrations were evaluated by Multiplex immunoassays in mother-infant pairs from the MAMI cohort in maternal plasma (MP) (n = 15) and umbilical cord plasma (UCP) (n = 15) at birth and in breast milk samples (n = 23) at days 7 and 15 postpartum. Data regarding mother and infant characteristics were collected. Gal-9 was present in a lower concentration range than Gal-1 and Gal-3 in plasma, specifically in UCP. A major finding in the current study is that Gal-1, -3 and -9 were detected for the first time in all the transitional breast milk samples and no differences were found when comparing the two breastfeeding time points. Finally, Gal levels were associated with some maternal and infant characteristics, such as gestational age, pregnancy weight gain, maternal diet, the gender, infant growth and infant infections. In conclusion, Gal levels seem to be involved in certain developmental aspects of early life. Keywords: galectin; breast milk; umbilical cord plasma; maternal plasma
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It is part of: Nutrients, 2022, vol. 14, num. 20
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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