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http://hdl.handle.net/2445/194015
Title: | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
Author: | Esteruelas Navarro, Gerard Souto, Eliana B. Espina García, Marta García López, María Luisa Switalska, Marta Wietrzyk, Joanna Gliszczyńska, Anna Sánchez-López, E. (Elena) |
Keywords: | Nanopartícules Sistemes d'alliberament de medicaments Nanoparticles Drug delivery systems |
Issue Date: | 1-Jan-2023 |
Publisher: | MDPI |
Abstract: | Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects. Keywords: diclofenac; nanoparticles; PLGA; anti-inflammatory; drug delivery; anti-angiogenesis; antitumoral |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics15010102 |
It is part of: | Pharmaceutics, 2023, vol. 15, num. 1 |
URI: | http://hdl.handle.net/2445/194015 |
Related resource: | https://doi.org/10.3390/pharmaceutics15010102 |
ISSN: | 1999-4923 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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