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Title: Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy
Author: Esteruelas Navarro, Gerard
Souto, Eliana B.
Espina García, Marta
García López, María Luisa
Switalska, Marta
Wietrzyk, Joanna
Gliszczyńska, Anna
Sánchez-López, E. (Elena)
Keywords: Nanopartícules
Sistemes d'alliberament de medicaments
Drug delivery systems
Issue Date: 1-Jan-2023
Publisher: MDPI
Abstract: Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects. Keywords: diclofenac; nanoparticles; PLGA; anti-inflammatory; drug delivery; anti-angiogenesis; antitumoral
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It is part of: Pharmaceutics, 2023, vol. 15, num. 1
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ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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