Please use this identifier to cite or link to this item:
Title: Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
Author: Caballero Hernández, Ana Belén
Gámez Enamorado, Patrick
Sabaté Lagunas, Raimon
Espargaró Colomé, Alba
Keywords: Amiloïdosi
Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 2022
Publisher: Springer Science + Business Media
Abstract: Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteria, namely, in bacterial inclusion bodies, offers the possibility to use bacteria as simple models to study amyloid aggregation processes and potential effects of both anti-amyloid drugs and/or pro-aggregative compounds. This chapter describes fast, simple, inexpensive, highly reproducible, and tunable in vitro and in cellulo methods that use bacterial inclusion bodies as preliminary screening tools for anti-amyloid drugs. Keywords: Amyloid aggregation; Bacterial inclusion body; Conformational disease; Drug screening.
Note: Versió postprint del document publicat a:
It is part of: Methods in Molecular Biology, 2022, vol. 2538, p. 165-188
Related resource:
ISSN: 1940-6029
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
724786.pdf647.01 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.