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http://hdl.handle.net/2445/194018
Title: | Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies |
Author: | Caballero, Ana B. Gámez Enamorado, Patrick Sabaté Lagunas, Raimon Espargaró Colomé, Alba |
Keywords: | Amiloïdosi Malaltia d'Alzheimer Amyloidosis Alzheimer's disease |
Issue Date: | 2022 |
Publisher: | Springer Science + Business Media |
Abstract: | Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteria, namely, in bacterial inclusion bodies, offers the possibility to use bacteria as simple models to study amyloid aggregation processes and potential effects of both anti-amyloid drugs and/or pro-aggregative compounds. This chapter describes fast, simple, inexpensive, highly reproducible, and tunable in vitro and in cellulo methods that use bacterial inclusion bodies as preliminary screening tools for anti-amyloid drugs. Keywords: Amyloid aggregation; Bacterial inclusion body; Conformational disease; Drug screening. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/978-1-0716-2529-3_12 |
It is part of: | Methods in Molecular Biology, 2022, vol. 2538, p. 165-188 |
URI: | http://hdl.handle.net/2445/194018 |
Related resource: | https://doi.org/10.1007/978-1-0716-2529-3_12 |
ISSN: | 1940-6029 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Química Inorgànica i Orgànica) |
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