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http://hdl.handle.net/2445/194108
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DC Field | Value | Language |
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dc.contributor.author | Sharma, Bunty | - |
dc.contributor.author | Samperi, Mario | - |
dc.contributor.author | Jain, Akhil | - |
dc.contributor.author | Chaudhary, Ganga Ram | - |
dc.contributor.author | Kaur, Gurpreet | - |
dc.contributor.author | Pérez García, M. Lluïsa (Maria Lluïsa) | - |
dc.date.accessioned | 2023-02-24T10:02:34Z | - |
dc.date.available | 2023-12-31T06:10:21Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | http://hdl.handle.net/2445/194108 | - |
dc.description.abstract | Photodynamic therapy (PDT) is an innovative technique for cancer treatment with minimal side effects, based on the use of a photosensitizer, oxygen, and light. Photosensitizers (PSs) have several limitations, that may limit their clinical use, like poor solubilization, self-aggregation, and lack of specific targeting, which can be addressed with the use of nanomaterials. Herein, a unique type of catansomes (CaSs) was prepared using a gemini imidazolium-based surfactant (1,3-bis[(3-octadecyl-1-imidazolio)methyl]benzene dibromide (GBIB) and a double chain surfactant, diaoctyl sodium sulfosuccinate or Aerosol OT (AOT). The formation of CaS GBIB/AOT was optimized in various ethanol/water (E/W) solvent ratios by employing a facile, quick, and most reliable solution-solution mixing method. The CaS was characterized by dynamic light scattering (DLS) and field emission gun scanning electron microscopy (FEG-SEM) techniques. The experimental results reveal that stable CaSs with a spherical shape were obtained at lower concentration (100 μM). Rose Bengal (RB), a PS of the xanthene family, was incorporated into these prepared CaSs, as proven by fluorescence spectroscopy, UV-visible absorption spectroscopy, and confocal laser scanning microscopy. Singlet oxygen (1O2) generation studies revealed the relevant role of the E/W solvent ratio as there was a 4-fold boost in the 1O2 production for GBIB/AOT in E/W = 50:50 and around 3-fold in E/W = 30:70. Also, the GBIB-rich 80:20 fraction was more efficient in increasing the 1O2 generation as compared to the AOT rich fraction (20:80). Further, their phototoxicity was tested in a water-rich solvent ratio (E/W = 30:70) against MCF-7 cells. Upon irradiation with a 532 nm laser (50 mW) for 5 min, RB@GBIB/AOT(20:80) fraction caused 50% decrease in the metabolic activity of MCF-7 cells, and RB@GBIB/AOT(80:20) fraction produced a maximum 85% decrease in cell viability. Furthermore, the enhancement in intracellular 1O2 generation by RB@GBIB/AOT, as compared to pure RB, was confirmed with singlet oxygen sensor green (SOSG). This new type of CaS based on gemini surfactants exhibiting a large amount of 1O2 generation, holds great interest for several applications, such as use in photomedicine in future. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acsbiomaterials.2c00017 | - |
dc.relation.ispartof | ACS Biomaterials-Science & Engineering, 2022, vol. 8, p. 1878-1891 | - |
dc.relation.uri | https://doi.org/10.1021/acsbiomaterials.2c00017 | - |
dc.rights | (c) American Chemical Society , 2022 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Compostos heterocíclics | - |
dc.subject.classification | Química farmacèutica | - |
dc.subject.other | Heterocyclic compounds | - |
dc.subject.other | Pharmaceutical chemistry | - |
dc.title | Gemini Surfactant Mediated Catansomes for Enhanced Singlet Oxygen Generation of Rose Bengal and Their Phototoxicity against Cancer Cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 729800 | - |
dc.date.updated | 2023-02-24T10:02:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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729800.pdf | 2.55 MB | Adobe PDF | View/Open |
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