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http://hdl.handle.net/2445/194142
Title: | C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. |
Author: | Baena, Esther Gandarillas, Alberto Vallespinós, Mireia Zanet, Jennifer Bachs Valldeneu, Oriol Redondo, Clara Fabregat Romero, Isabel Martinez-A., Carlos Moreno de Alboran, Ignacio |
Keywords: | Cèl·lules Factors de transcripció Cicle cel·lular Fetge Proliferació cel·lular Cells Transcription factors Cell cycle Liver Cell proliferation |
Issue Date: | 17-May-2005 |
Publisher: | National Academy of Sciences |
Abstract: | The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth. |
Note: | Reproducció del document publicat a: https://doi.org/10.1073/pnas.0409260102 |
It is part of: | Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 20, p. 7286-7291 |
URI: | http://hdl.handle.net/2445/194142 |
Related resource: | https://doi.org/10.1073/pnas.0409260102 |
ISSN: | 0027-8424 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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