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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/194162
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dc.contributor.authorTrejo, Angela-
dc.contributor.authorMasdeu, Carme-
dc.contributor.authorSerrano-Pérez, Irene-
dc.contributor.authorPedrola, Marina-
dc.contributor.authorJuanola, Narcís-
dc.contributor.authorGhashgaei, Ouldouz-
dc.contributor.authorJiménez Galisteo, Mª Guadalupe-
dc.contributor.authorLavilla Grífols, Rodolfo-
dc.contributor.authorPalacios, Francisco-
dc.contributor.authorAlonso, Concepción-
dc.contributor.authorViñas, Miquel-
dc.date.accessioned2023-02-24T18:41:57Z-
dc.date.available2023-02-24T18:41:57Z-
dc.date.issued2023-01-03-
dc.identifier.issn2079-6382-
dc.identifier.urihttp://hdl.handle.net/2445/194162-
dc.description.abstractNew antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria.-
dc.format.extent14 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/antibiotics12010083-
dc.relation.ispartofAntibiotics, 2023, vol. 12, p. 83-
dc.relation.urihttps://doi.org/10.3390/antibiotics12010083-
dc.rightscc-by (c) Trejo, Angela et al., 2023-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationAntibiòtics-
dc.subject.classificationMedicaments-
dc.subject.classificationMicobacteris-
dc.subject.otherAntibiotics-
dc.subject.otherDrugs-
dc.subject.otherMycobacteria-
dc.titleEfficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec727886-
dc.date.updated2023-02-24T18:41:57Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid36671284-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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