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http://hdl.handle.net/2445/194239
Title: | Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance |
Author: | Nguyen, Mai K. Jose, Jaimy Wahba, Mohamed Bernaus Esqué, Marc Hoy, Andrew J. Enrich Bastús, Carles Rentero Alfonso, Carles Grewal, Thomas |
Keywords: | Proteïnes supressores de tumors Colesterol Cèl·lules canceroses Proteïnes portadores Tumor suppressor protein Cholesterol Cancer cells Carrier proteins |
Issue Date: | 29-Jun-2022 |
Publisher: | MDPI |
Abstract: | Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs, contributing to resistance to therapies. This includes a higher demand for cholesterol, which often coincides with elevated cholesterol uptake from low-density lipoproteins (LDL) and overexpression of the LDL receptor in many cancers. This implies the need for cancer cells to accommodate an increased delivery of LDL along the endocytic pathway to late endosomes/lysosomes (LE/Lys), providing a rapid and effective distribution of LDL-derived cholesterol from LE/Lys to other organelles for cholesterol to foster cancer growth and spread. LDL-cholesterol exported from LE/Lys is facilitated by Niemann-Pick Type C1/2 (NPC1/2) proteins, members of the steroidogenic acute regulatory-related lipid transfer domain (StARD) and oxysterol-binding protein (OSBP) families. In addition, lysosomal membrane proteins, small Rab GTPases as well as scaffolding proteins, including annexin A6 (AnxA6), contribute to regulating cholesterol egress from LE/Lys. Here, we summarize current knowledge that links upregulated activity and expression of cholesterol transporters and related proteins in LE/Lys with cancer growth, progression and treatment outcomes. Several mechanisms on how cellular distribution of LDL-derived cholesterol from LE/Lys influences cancer cell behavior are reviewed, some of those providing opportunities for treatment strategies to reduce cancer progression and anticancer drug resistance. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms23137206 |
It is part of: | International Journal of Molecular Sciences, 2022, vol. 23, num. 13, p. 7206 |
URI: | http://hdl.handle.net/2445/194239 |
Related resource: | https://doi.org/10.3390/ijms23137206 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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