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http://hdl.handle.net/2445/194309
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DC Field | Value | Language |
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dc.contributor.author | Trias-Sabrià, Pere | - |
dc.contributor.author | Dorca Duch, Eduard | - |
dc.contributor.author | Molina Molina, María | - |
dc.contributor.author | Aso, Samantha | - |
dc.contributor.author | Díez-Ferrer, Marta | - |
dc.contributor.author | Marin, Alfredo | - |
dc.contributor.author | Bordas-Martínez, Jaume | - |
dc.contributor.author | Sabater, Joan | - |
dc.contributor.author | Luburich, Patricio | - |
dc.contributor.author | Del Río, Belén | - |
dc.contributor.author | Dorca i Sargatal, Jordi | - |
dc.contributor.author | Santos Perez, Maria De La S. | - |
dc.contributor.author | Suarez-Cuartin, Guillermo | - |
dc.date.accessioned | 2023-02-28T09:58:40Z | - |
dc.date.available | 2023-02-28T09:58:40Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | http://hdl.handle.net/2445/194309 | - |
dc.description.abstract | Background: Patients with coronavirus disease 2019 (COVID-19) can develop severe bilateral pneumonia leading to respiratory failure. Lung histological samples were scarce due to the high risk of contamination during autopsies. We aimed to correlate histological COVID-19 features with radiological findings through lung ultrasound (LU)-guided postmortem core needle biopsies (CNBs) and computerized tomography (CT) scans. Methodology: We performed an observational prospective study, including 30 consecutive patients with severe COVID-19. The thorax was divided into 12 explorations regions to correlate LU and CT-scan features. Histological findings were also related to radiological features through CNBs. Results: Mean age was 62.56 ± 13.27 years old, with 96.7% male patients. Postmortem LU-guided CNBs were performed in 13 patients. Thirty patients were evaluated with both thoracic LU and chest CT scan, representing a total of 279 thoracic regions explored. The most frequent LU finding was B2-lines (49.1%). The most CT-scan finding was ground-glass opacity (GGO, 29%). Pathological CT-scan findings were commonly observed when B2-lines or C-lines were identified through LU (positive predictive value, PPV, 87.1%). Twenty-five postmortem echo-guided histological samples were obtained from 12 patients. Histological samples showed diffuse alveolar damage (DAD) (75%) and chronic interstitial inflammation (25%). The observed DAD was heterogeneous, showing multiple evolving patterns of damage, including exudative (33.3%), fibrotic (33.3%), and organizing (8.3%) phases. In those patients with acute or exudative pattern, two lesions were distinguished: classic hyaline membrane; fibrin "plug" in alveolar space (acute fibrinous organizing pneumonia, AFOP). C-profile was described in 33.3% and presented histological signs of DAD and lung fibrosis. The predominant findings were collagen deposition (50%) and AFOP (50%). B2-lines were identified in 66.7%; the presence of hyaline membrane was the predominant finding (37.5%), then organizing pneumonia (12.5%) and fibrosis (37.5%). No A-lines or B1-lines were observed in these patients. Conclusion: LU B2-lines and C-profile are predominantly identified in patients with severe COVID-19 with respiratory worsening, which correspond to different CT patterns and histological findings of DAD and lung fibrosis. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fmed.2022.820661 | - |
dc.relation.ispartof | Frontiers in Medicine, 2022, vol. 9 | - |
dc.relation.uri | https://doi.org/10.3389/fmed.2022.820661 | - |
dc.rights | cc-by (c) Trias-Sabrià, Pere et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Biòpsia | - |
dc.subject.classification | Patologia | - |
dc.subject.classification | Radiologia | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Biopsy | - |
dc.subject.other | Pathology | - |
dc.subject.other | Radiology | - |
dc.title | Radio-histological correlation of lung features in severe COVID19 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 717350 | - |
dc.date.updated | 2023-02-28T09:58:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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717350.pdf | 2.28 MB | Adobe PDF | View/Open |
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