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Title: | Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers |
Author: | Garrido, Alicia Pérez Sisqués, Leticia Simonet, Cristina Campoy Campos, Genís Solana Balaguer, Júlia Martín Flores, Núria Fernández, Manel Soto, Marta Obiang, Donina Camara, Ana Valldeoriola Serra, Francesc Muñoz, Esteban Compta, Yaroslau Pérez Navarro, Esther Alberch i Vié, Jordi, 1959- Tolosa, Eduardo Martí Domènech, Ma. Josep Ezquerra, Mario Malagelada Grau, Cristina Fernández Santiago, Rubén |
Keywords: | Malaltia de Parkinson Mutació (Biologia) Proteïnes portadores Cèl·lules sanguínies Nervis perifèrics Parkinson's disease Mutation (Biology) Carrier proteins Blood cells Peripheral nerves |
Issue Date: | Nov-2022 |
Publisher: | Wiley-Liss |
Abstract: | The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from patients with G2019S LRRK2-associated PD (L2PD, n = 31), G2019S LRRK2 non-manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P-Ser-935-LRRK2 between groups but detected a specific increase of P-Ser-473-AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P-Ser-473-AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888-894. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ana.26469 |
It is part of: | Annals of Neurology, 2022, vol. 92, num. 5, p. 888-894 |
URI: | http://hdl.handle.net/2445/194378 |
Related resource: | https://doi.org/10.1002/ana.26469 |
ISSN: | 0364-5134 |
Appears in Collections: | Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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