Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/194392
Title: Circulating inflammatory cells in patients with metastatic breast cancer: Implications for treatment
Author: Gianni, Caterina
Palleschi, Michela
Schepisi, Giuseppe
Casadei, Chiara
Bleve, Sara
Merloni, Filippo
Sirico, Marianna
Sarti, Samanta
Cecconetto, Lorenzo
Di Menna, Giandomenico
Schettini, Francesco
De Giorgi, Ugo
Keywords: Marcadors bioquímics
Macròfags
Limfòcits
Metàstasi
Càncer de mama
Biochemical markers
Macrophages
Lymphocytes
Metastasis
Breast cancer
Issue Date: 8-Aug-2022
Publisher: Frontiers Media
Abstract: Adaptive and innate immune cells play a crucial role as regulators of cancer development. Inflammatory cells in blood flow seem to be involved in pro-tumor activities and contribute to breast cancer progression. Circulating lymphocyte ratios such as the platelet-lymphocytes ratio (PLR), the monocyte-lymphocyte ratio (MLR) and the neutrophil-lymphocyte ratio (NLR) are new reproducible, routinely feasible and cheap biomarkers of immune response. These indexes have been correlated to prognosis in many solid tumors and there is growing evidence on their clinical applicability as independent prognostic markers also for breast cancer. In this review we give an overview of the possible value of lymphocytic indexes in advanced breast cancer prognosis and prediction of outcome. Furthermore, targeting the immune system appear to be a promising therapeutic strategy for breast cancer, especially macrophage-targeted therapies. Herein we present an overview of the ongoing clinical trials testing systemic inflammatory cells as therapeutic targets in breast cancer.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fonc.2022.882896
It is part of: Frontiers In Oncology, 2022, vol. 12, p. 882896
URI: http://hdl.handle.net/2445/194392
Related resource: https://doi.org/10.3389/fonc.2022.882896
ISSN: 2234-943X
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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