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http://hdl.handle.net/2445/194890
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DC Field | Value | Language |
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dc.contributor.author | Hüll, Katharina | - |
dc.contributor.author | Fernández Dueñas, Víctor | - |
dc.contributor.author | Schönberger, Matthias | - |
dc.contributor.author | López-Cano, Marc | - |
dc.contributor.author | Trauner, Dirk | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2023-03-08T16:07:40Z | - |
dc.date.available | 2023-03-08T16:07:40Z | - |
dc.date.issued | 2021-12-01 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/2445/194890 | - |
dc.description.abstract | Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent agonists for ARs and confer optical control to these G protein-coupled receptors. One of our compounds, AzoAdenosine-3, was evaluated in the classical formalin model of pain. The molecule, active in the dark, was not metabolized by adenosine deaminase and effectively reduced pain perception in a light-dependent manner. These antinociceptive effects suggested a major role for A1R and A3R in peripheralmediated pain sensitization, whereas an average adenosine-mediated antinociceptive effect will be facilitated by A2AR and A2BR. Our results demonstrate that a photoswitchable adenosine derivative can be used to map the contribution of ARs mediating analgesia in vivo. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1021/acs.bioconjchem.1c00387 | - |
dc.relation.ispartof | Bioconjugate Chemistry, 2021, vol. 32, num. 9, p. 1-5 | - |
dc.relation.uri | https://doi.org/10.1021/acs.bioconjchem.1c00387 | - |
dc.rights | cc by (c) Hüll, Katharina et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Adenosina | - |
dc.subject.classification | Tractament del dolor | - |
dc.subject.classification | Fisiologia | - |
dc.subject.other | Adenosine | - |
dc.subject.other | Pain treatment | - |
dc.subject.other | Physiology | - |
dc.title | Optical control of adenosine-mediated pain modulation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714961 | - |
dc.date.updated | 2023-03-08T16:07:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34448572 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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714961.pdf | 2.21 MB | Adobe PDF | View/Open |
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