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Title: | Contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors CD5 and CD6 |
Author: | Casadó Llombart, Sergi Velasco de Andrés, María Català, Cristina Leyton Pereira, Alejandra Lozano Soto, Francisco Bosch, Elena |
Keywords: | Antigen CD5 Antígens CD Malalties autoimmunitàries Cèl·lules canceroses Genètica humana Resposta immunitària Infeccions Selecció natural Nucleòtids CD5 antigen CD antigens Autoimmune diseases Cancer cells Human genetics Immune response Infections Natural selection Nucleotides |
Issue Date: | 18-May-2021 |
Publisher: | MDPI |
Abstract: | Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively selected immune gene variants conferring increased resistance to past or present infectious agents are today associated with increased risk for autoimmune or inflammatory disorders but decreased risk of cancer, the other side of the same coin. CD5 and CD6 are lymphocytic scavenger receptors at the interphase of the innate and adaptive immune responses since they are involved in both: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by the clonotypic antigen-specific receptor present in T and B cells (TCR and BCR, respectively). Here, we review available information on CD5 and CD6 as targets of natural selection as well as on the role of CD5 and CD6 variation in autoimmunity and cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22105315 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num. 10, p. 5315 |
URI: | http://hdl.handle.net/2445/194991 |
Related resource: | https://doi.org/10.3390/ijms22105315 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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