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Title: | Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure. |
Author: | Calvo Escalona, Rosa Lázaro García, Luisa Hoogman, Martine Van Rooij, Daan Klein, Marieke Boedhoe, Premika S. W. Ilioska, Iva Li, Ting Patel, Yash Postema, Merel C. Zhang-James, Yanli Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Banaschewski, Tobias Bau, Claiton Henrique Dotto Behrmann, Marlene Bellgrove, Mark A. Brandeis, Daniel Brem, Silvia Busatto, Geraldo F. Calderoni, Sara Castellanos, Francisco X. Daly, Eileen Coghill, D. Conzelmann, Annette Deruelle, Christine Dinstein, Illan Durston, Sarah Ecker, Christine Ehrlich, Stefan Epstein, Jeffery N. Fair, Damien FitzGerald, Jackie Freitag, Christine M. Frodl, Thomas Gallagher, Louise Grevet, Eugenio Horacio Haavik, Jan Ramos Quiroga, Josep Antoni |
Keywords: | Trastorns per dèficit d'atenció amb hiperactivitat en els adults Trastorns de l'espectre autista Escorça cerebral Neurociències Attention deficit disorder with hyperactivity in adults Autism spectrum disorders Cerebral cortex Neurosciences |
Issue Date: | 18-May-2020 |
Publisher: | Wiley |
Abstract: | Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/hbm.25029 |
It is part of: | Human Brain Mapping, 2020, vol. 43, num. 1, p. 37-55 |
URI: | http://hdl.handle.net/2445/195260 |
Related resource: | https://doi.org/10.1002/hbm.25029 |
ISSN: | 1065-9471 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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