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Title: | Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era |
Author: | Izquierdo, Conchita Ciruela, Pilar Hernández, Sergi García García, Juan José Esteva, Cristina Moraga Llop, Fernando A. Díaz Conradi, Álvaro Martínez Osorio, Johanna Solé Ribalta, Anna Fernández de Sevilla, Mariona González-Peris, Sebastià Codina Grau, Maria Gemma Planes, Ana María Uriona, Sonia Campins Martí, Magda Muñoz Almagro, Carmen Salleras i Sanmartí, Lluís Domínguez García, Àngela |
Keywords: | Infants Infeccions per pneumococs Vacuna antipneumocòccica Pneumococs Penicil·lina Identificació dels microoganismes Children Pneumococcal Infections Pneumococcal vaccine Streptococcus pneumonia Penicillin Microorganisms identification |
Issue Date: | 5-Nov-2020 |
Publisher: | Cambridge University Press |
Abstract: | The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33-22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56-8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2-4 years and 5-17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored. |
Note: | Reproducció del document publicat a: https://doi.org/10.1017/S0950268820002708 |
It is part of: | Epidemiology and Infection, 2020, vol. 148, p. e279 |
URI: | http://hdl.handle.net/2445/195333 |
Related resource: | https://doi.org/10.1017/S0950268820002708 |
ISSN: | 0950-2688 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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