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http://hdl.handle.net/2445/195421
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DC Field | Value | Language |
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dc.contributor.author | Angulo, Guillem | - |
dc.contributor.author | Zeleznjak, Jelena | - |
dc.contributor.author | Martínez Vicente, Pablo | - |
dc.contributor.author | Puñet Ortiz, Joan | - |
dc.contributor.author | Hengel, Hartmut | - |
dc.contributor.author | Messerle, Martin | - |
dc.contributor.author | Oxenius, Annette | - |
dc.contributor.author | Jonjic, Stipan | - |
dc.contributor.author | Krmpotić, Astrid | - |
dc.contributor.author | Engel Rocamora, Pablo | - |
dc.contributor.author | Angulo Aguado, Ana | - |
dc.date.accessioned | 2023-03-16T14:41:14Z | - |
dc.date.available | 2023-03-16T14:41:14Z | - |
dc.date.issued | 2021-01-18 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/2445/195421 | - |
dc.description.abstract | Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated during infection of antigen-presenting cells by different herpesviruses. We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr-1 physically interacts with ICOSL, impeding its maturation and promoting its lysosomal degradation. This viral protein counteracts T-cell responses, in an ICOS-dependent manner, and limits virus control during the acute MCMV infection. Additionally, we report that blockade of ICOSL in MCMV-infected mice critically regulates the production of MCMV-specific antibodies due to a reduction of T follicular helper and GC B cells. Altogether, these findings reveal a novel mechanism evolved by MCMV to counteract adaptive immune surveillance, and demonstrates a role of the ICOS:ICOSL axis in the host defense against herpesviruses. | - |
dc.format.extent | 38 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.7554/eLife.59350 | - |
dc.relation.ispartof | eLife, 2021, vol. 10, num. e59350 | - |
dc.relation.uri | https://doi.org/10.7554/eLife.59350 | - |
dc.rights | cc-by (c) Angulo, Guillem et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Antígens | - |
dc.subject.classification | Citomegalovirus | - |
dc.subject.classification | Herpesvirus | - |
dc.subject.classification | Immunitat cel·lular | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Malalties víriques | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.other | Antigens | - |
dc.subject.other | Cytomegaloviruses | - |
dc.subject.other | Herpesviruses | - |
dc.subject.other | Cellular immunity | - |
dc.subject.other | Inflammation | - |
dc.subject.other | T cells | - |
dc.subject.other | Virus diseases | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.title | Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 710580 | - |
dc.date.updated | 2023-03-16T14:41:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33459589 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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710580.pdf | 3.34 MB | Adobe PDF | View/Open |
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