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http://hdl.handle.net/2445/195425
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DC Field | Value | Language |
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dc.contributor.author | Wierenga, Lara M. | - |
dc.contributor.author | Doucet, Gaelle E. | - |
dc.contributor.author | Dima, Danai | - |
dc.contributor.author | Agartz, Ingrid | - |
dc.contributor.author | Aghajani, Moji | - |
dc.contributor.author | Akudjedu, Theophilus N. | - |
dc.contributor.author | Albajes Eizagirre, Anton | - |
dc.contributor.author | Alnaes, Dag | - |
dc.contributor.author | Alpert, Kathryn I. | - |
dc.contributor.author | Andreassen, Ole A. | - |
dc.contributor.author | Anticevic, Alan | - |
dc.contributor.author | Asherson, Philip | - |
dc.contributor.author | Banaschewski, Tobias | - |
dc.contributor.author | Bargalló Alabart, Núria | - |
dc.contributor.author | Baumeister, Sarah | - |
dc.contributor.author | Baur Streubel, Ramona | - |
dc.contributor.author | Bertolino, Alessandro | - |
dc.contributor.author | Bonvino, Aurora | - |
dc.contributor.author | Boomsma, Dorret I. | - |
dc.contributor.author | Borgwardt, Stefan | - |
dc.contributor.author | Bourque, Josiane | - |
dc.contributor.author | den Braber, Anouk | - |
dc.contributor.author | Brandeis, Daniel | - |
dc.contributor.author | Breier, Alan | - |
dc.contributor.author | Brodaty, Henry | - |
dc.contributor.author | Brouwer, Rachel M. | - |
dc.contributor.author | Buitelaar, Jan K. | - |
dc.contributor.author | Busatto, Geraldo F. | - |
dc.contributor.author | Canales Rodríguez, Erick Jorge | - |
dc.contributor.author | Cannon, Dara M. | - |
dc.contributor.author | Caseras, Xavier | - |
dc.contributor.author | Castellanos, Francisco X. | - |
dc.contributor.author | Radua, Joaquim | - |
dc.contributor.author | Chaim-Avancini, Tiffany M. | - |
dc.contributor.author | Ching, Christopher R. K. | - |
dc.contributor.author | Lázaro García, Luisa | - |
dc.contributor.author | Martínez Zalacaín, Ignacio | - |
dc.contributor.author | Menchón Magriñá, José Manuel | - |
dc.contributor.author | Soriano Mas, Carles | - |
dc.contributor.author | Karolinska Schizophrenia Project (KaSP) | - |
dc.date.accessioned | 2023-03-16T15:30:14Z | - |
dc.date.available | 2023-03-16T15:30:14Z | - |
dc.date.issued | 2020-10-12 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | http://hdl.handle.net/2445/195425 | - |
dc.description.abstract | For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/hbm.25204 | - |
dc.relation.ispartof | Human Brain Mapping, 2020, vol. 43, num. 1, p. 470-499 | - |
dc.relation.uri | https://doi.org/10.1002/hbm.25204 | - |
dc.rights | cc-by (c) Wierenga, Lara M. et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Evolució del cervell | - |
dc.subject.classification | Anàlisi de variància | - |
dc.subject.classification | Diferències entre sexes | - |
dc.subject.classification | Cervell | - |
dc.subject.other | Evolution of the brain | - |
dc.subject.other | Analysis of variance | - |
dc.subject.other | Sex differences | - |
dc.subject.other | Brain | - |
dc.title | Greater male than female variability in regional brain structure across the lifespan | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709878 | - |
dc.date.updated | 2023-03-16T15:30:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33044802 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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709878.pdf | 4.38 MB | Adobe PDF | View/Open |
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