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http://hdl.handle.net/2445/195427
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DC Field | Value | Language |
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dc.contributor.author | Montagud Marrahi, Enrique | - |
dc.contributor.author | Molina Andújar, Alícia | - |
dc.contributor.author | Pané, Adriana | - |
dc.contributor.author | Ramírez-Bajo MJ | - |
dc.contributor.author | Amor, Antonio | - |
dc.contributor.author | Esmatjes Mompó, Enric | - |
dc.contributor.author | Ferrer Fábrega, Joana | - |
dc.contributor.author | Musquera i Felip, Mireia | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.contributor.author | Ventura Aguiar, Pedro | - |
dc.date.accessioned | 2023-03-16T15:46:10Z | - |
dc.date.available | 2023-03-16T15:46:10Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2052-4897 | - |
dc.identifier.uri | http://hdl.handle.net/2445/195427 | - |
dc.description.abstract | Objective: Improvement in insulin alternatives is leading to a delayed presentation of microvascular and macrovascular complications of diabetes. The objective of this study was to evaluate the long-term outcomes of older (≥50 years) diabetic patients who receive a pancreas transplantation (PT). Research design and methods: We retrospectively evaluated all 338 PTs performed at our center between 2000 and 2016 (mean follow-up 9.4±4.9 years). Recipient and graft survivals were estimated for up to 10 years after PT. Major adverse cardiovascular events (MACEs) before and after PT were included in the analysis. Results: Thirty-nine patients (12%) were ≥50 years old (52.7±2.3 years) at the day of PT, of which 29 received a simultaneous pancreas-kidney transplantation (SPK) and 10 a pancreas after kidney transplantation (PAK). SPK recipients were first transplants, whereas in the PAK up to 50% were pancreas re-transplantations. Recipient and pancreas graft survivals at 10 years were similar between the group <50 years old and the older group for both SPK and PAK (log-rank p>0.05). The prevalence of MACE prior to PT was similar between both groups (31% vs 29%). Following PT, older recipients presented inferior post-transplant MACE-free survival. In a multivariate regression model, diabetes vintage (HR 1.054, p=0.03) and pre-transplantation MACE (HR 1.98, p=0.011), but not recipient age (HR 1.45, p=0.339), were associated with post-transplant MACE. Conclusions: Long-term survival of older pancreas transplant recipients are similar to younger counterparts. Diabetes vintage, but not age, increased the risk of post-transplantation MACE. These results suggest pancreas transplantation is a valuable treatment alternative to older diabetic patients. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/bmjdrc-2019-000916 | - |
dc.relation.ispartof | BMJ Open Diabetes Research & Care, 2020, vol. 8, num. 1, p. e000916 | - |
dc.relation.uri | https://doi.org/10.1136/bmjdrc-2019-000916 | - |
dc.rights | cc-by-nc (c) Montagud Marrahi, Enrique et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Pàncrees | - |
dc.subject.classification | Trasplantament d'òrgans | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Persones grans | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Pancreas | - |
dc.subject.other | Transplantation of organs | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Older people | - |
dc.subject.other | Cardiovascular diseases | - |
dc.title | Outcomes of pancreas transplantation in older diabetic patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708893 | - |
dc.date.updated | 2023-03-16T15:46:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32144128 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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708893.pdf | 941.1 kB | Adobe PDF | View/Open |
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