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Title: Relationship of adverse events to quality of anticoagulation control in atrial fibrillation patients with diabetes: real-world data from the FANTASIIA Registry
Author: García-Fernández, Amaya
Esteve-Pastor, María Asunción
Roldán-Rabadán, Inmaculada
Muñiz, Javier
Ruiz Ortiz, Martín
Cequier Fillat, Àngel R.
Bertomeu-Martínez, Vicente
Badimón, Lina, 1953-
Otero, Deborah
Anguita Sánchez, Manuel
Lip, Gregory Y.H.
Marín, Francisco
FANTASIIA Study Investigators
Keywords: Fibril·lació auricular
Atrial fibrillation
Issue Date: Sep-2020
Publisher: Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i de Balears
Abstract: Background: Atrial fibrillation (AF) patients with diabetes (DM) have high risk of cardiovascular events. Purpose To compare clinical characteristics, adverse outcomes and quality of anticoagulation in AF patients regarding DM status. Methods: AF patients from FANTASIIA registry were included. Baseline characteristics and comorbidities were recorded. After 2-years follow-up, the association between adverse events and DM was evaluated. Results: 1956 patients (mean age 73.8 ± 9.5 years, 56% male) were analyzed; 574 (29.3%) had DM. Diabetic patients had also high prevalence of hypertension (90.6% vs 76.1%; p < .001) or renal disease (21.4% vs 15.9%; p < .001). After median follow-up of 1077 days (IQR 766-1113 days), diabetic patients had high total mortality (16.9%/year vs 11.4%/year; p < .001), cardiovascular mortality (9.1%/year vs 3.9%/year; p < .001) and MACE (12.9%/year vs 6.8%/year; p < .001). DM patients had poor anticoagulation control (time in therapeutic range: 58.52 ± 24.37% vs 62.68 ± 25.31%; p = .002). DM with lower TTR showed higher cardiovascular death and MACE. Multivariate analysis showed an independent association between DM and cardiovascular mortality [HR 1.73 (IC95% 1.07-2.80); p = .024]. Conclusion: AF Diabetic patients have higher comorbidities and poorer TTR than nondiabetic patients. Low TTR was associated with adverse events. The risk of cardiovascular outcomes was higher in DM patients, with independent association between DM and mortality risk.
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It is part of: Annals de Medicina, 2020, vol. 52, num. 6, p. 300-309
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ISSN: 0210-7465
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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