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Title: | The U-shaped relationship between parental age and the risk of bipolar disorder in the offspring: A systematic review and meta-analysis |
Author: | Fico, Giovanna Oliva, Vincenzo De Prisco, Michele Giménez Palomo, Anna Sagué Vilavella, Maria Gomes da Costa, Susana Garriga, Marina Solé, Eva Valentí Ribas, Marc Fanelli, Giuseppe Serretti, Alessandro Fornaro, Michele Carvalho, André F. Vieta i Pascual, Eduard, 1963- Murru, Andrea |
Keywords: | Transistors bipolars Metaanàlisi Maternitat Paternitat Factors d'edat en les malalties Bipolar transistors Meta-analysis Motherhood Fatherhood Age factors in disease |
Issue Date: | 26-May-2022 |
Publisher: | Elsevier B.V. |
Abstract: | Parenthood age may affect the risk for the development of different psychiatric disorders in the offspring, including bipolar disorder (BD). The present systematic review and meta-analysis aimed to appraise the relationship between paternal age and risk for BD and to explore the eventual relationship between paternal age and age at onset of BD. We searched the MEDLINE, Scopus, Embase, PsycINFO online databases for original studies from inception, up to December 2021. Random-effects meta-analyses were conducted. Sixteen studies participated in the qualitative synthesis, of which k = 14 fetched quantitative data encompassing a total of 13,424,760 participants and 217,089 individuals with BD. Both fathers [adjusted for the age of other parent and socioeconomic status odd ratio - OR = 1.29(95%C.I. = 1.13-1.48)] and mothers aged ≤ 20 years [(OR = 1.23(95%C.I. = 1.14-1.33)] had consistently increased odds of BD diagnosis in their offspring compared to parents aged 25-29 years. Fathers aged ≥ 45 years [adjusted OR = 1.29 (95%C.I. = 1.15-1.46)] and mothers aged 35-39 years [OR = 1.10(95%C.I. = 1.01-1.19)] and 40 years or older [OR = 1.2(95% C.I. = 1.02-1.40)] likewise had inflated odds of BD diagnosis in their offspring compared to parents aged 25-29 years. Early and delayed parenthood are associated with an increased risk of BD in the offspring. Mechanisms underlying this association are largely unknown and may involve a complex interplay between psychosocial, genetic and biological factors, and with different impacts according to sex and age range. Evidence on the association between parental age and illness onset is still tentative but it points towards a possible specific effect of advanced paternal age on early BD-onset. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2022.05.004 |
It is part of: | European Neuropsychopharmacology, 2022, vol. 60, p. 55-75 |
URI: | http://hdl.handle.net/2445/195594 |
Related resource: | https://doi.org/10.1016/j.euroneuro.2022.05.004 |
ISSN: | 0924-977X |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Medicina) |
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