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Title: | Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2-59 Months of Age, Spain |
Author: | Hernández, Sergi Moraga Llop, Fernando A. Díaz, A. de Sevilla, Mariona F. Ciruela, Pilar Muñoz Almagro, Carmen Codina Grau, Maria Gemma Campins Martí, Magda García García, Juan José Esteva, Cristina Izquierdo, Conchita González Peris, Sebastià Martínez Osorio, Johanna Uriona, Sonia Salleras i Sanmartí, Lluís Domínguez García, Àngela |
Keywords: | Reacció en cadena de la polimerasa Espanya Pneumococs Vacunes antibacterianes Pneumònia Infeccions respiratòries Infeccions per estreptococs Vacunació dels infants Polymerase chain reaction Spain Streptococcus pneumonia Bacterial vaccines Pneumonia Respiratory infections Streptococcal infections Vaccination of children |
Issue Date: | Jun-2020 |
Publisher: | Centers for Disease Control and Prevention |
Abstract: | Vaccination with the 13-valent conjugated pneumococcal disease (PCV13) has reduced invasive pneumococcal disease (IPD), but there have been reports of vaccine failures. We performed a prospective study in children aged 2-59 months who received diagnoses of IPD during January 2012-June 2016 in 3 pediatric hospitals in Catalonia, Spain, a region with a PCV13 vaccination coverage of 63%. We analyzed patients who had been age-appropriately vaccinated but who developed IPD caused by PCV13 serotypes. We detected 24 vaccine failure cases. The serotypes involved were 3 (16 cases); 19A (5 cases); and 1, 6B, and 14 (1 case each). Cases were associated with children without underlying conditions, with complicated pneumonia (OR 6.65, 95% CI 1.91-23.21), and with diagnosis by PCR (OR 5.18, 95% CI 1.84-14.59). Vaccination coverage should be increased to reduce the circulation of vaccine serotypes. Continuous surveillance of cases of IPD using both culture and PCR to characterize vaccine failures is necessary. |
Note: | Reproducció del document publicat a: https://doi.org/10.3201/eid2606.190951 |
It is part of: | Emerging Infectious Diseases, 2020, vol. 26, num. 6, p. 1147-1155 |
URI: | http://hdl.handle.net/2445/196032 |
Related resource: | https://doi.org/10.3201/eid2606.190951 |
ISSN: | 1080-6040 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Medicina) |
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