Please use this identifier to cite or link to this item:
Title: Protected syn-aldol compounds from direct, catalytic, and enantioselective reactions of N-acyl-1,3-oxazinane-2-thiones with aromatic acetals
Author: Mellado Hidalgo, Miguel
Romero Cavagnaro, Elias A.
Nageswaran, Sajanthanaa
Puddu, Sabrina
Kennington, Stuart C. D.
Costa i Arnau, Anna M.
Romea, Pedro
Urpí Tubella, Fèlix
Aullón López, Gabriel
Font Bardia, Ma. Mercedes
Keywords: Aldehids
Estructura molecular
Molecular structure
Issue Date: 26-Jan-2023
Publisher: American Chemical Society
Abstract: A direct and asymmetric syn-aldol reaction of N-acyl-1,3-oxazinane-2-thiones with dialkyl acetals from aromatic acetals in the presence of 2-5 mol % [DTBM-SEGPHOS]NiCl2, TMSOTf, and lutidine has been developed. It has been established that the oxazinanethione heterocycle, used for the first time as a scaffold in asymmetric carbon-carbon bond-forming reactions, can be smoothly removed to give access to a variety of enantiomerically pure compounds with high synthetic value.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2023, vol. 23, num. 4, p. 659-664
Related resource:
ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
729383.pdf1.56 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.