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https://hdl.handle.net/2445/196247
Title: | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis. |
Author: | Rapado-Castro, Marta Villar Arenzana, Mara Janssen, Joost Fraguas, David Bombin, Igor Castro Fornieles, Josefina Mayoral, María González-Pinto, Ana Serna, Elena de la Parellada, Mara Moreno, Dolores Payá, Beatriz Graell, Montserrat Baeza, Inmaculada, 1970- Pantelis, Christos Arango, Celso |
Keywords: | Psicosi en els adolescents Trastorns per dèficit d'atenció en els adolescents Evolució del cervell Trastorns de la memòria Imatges per ressonància magnètica Psychoses in adolescence Attention-deficit disorder in adolescence Evolution of the brain Memory disorders Magnetic resonance imaging |
Issue Date: | 31-Aug-2021 |
Publisher: | MDPI |
Abstract: | Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, p = 0.008); right (B = 0.089, p = 0.015); parietal left (B = 0.119, p = 0.007), right (B = 0.125, p = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10173929 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10, num. 17, p. 3929 |
URI: | https://hdl.handle.net/2445/196247 |
Related resource: | https://doi.org/10.3390/jcm10173929 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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