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DC Field | Value | Language |
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dc.contributor.author | Ribera, Aida | - |
dc.contributor.author | Ferreira-Gonzalez, Ignacio | - |
dc.contributor.author | Marsal, Josep Ramon | - |
dc.contributor.author | Oristrell, Gerard | - |
dc.contributor.author | Teresa Faixedas, Maria | - |
dc.contributor.author | Rosas, Alba | - |
dc.contributor.author | Tizón Marcos, Helena | - |
dc.contributor.author | Rojas, Sergio | - |
dc.contributor.author | Labata, Carlos | - |
dc.contributor.author | Cardenas, Merida | - |
dc.contributor.author | Homs, Silvia | - |
dc.contributor.author | Tomas-Querol, Carlos | - |
dc.contributor.author | Garcia-Picart, Joan | - |
dc.contributor.author | Gómez Hospital, Joan Antoni | - |
dc.contributor.author | Pijoan, Jose Ignacio | - |
dc.contributor.author | Masotti, Monica | - |
dc.contributor.author | Mauri Ferré, Josepa | - |
dc.contributor.author | García Dorado, David | - |
dc.date.accessioned | 2023-04-06T16:42:03Z | - |
dc.date.available | 2023-04-06T16:42:03Z | - |
dc.date.issued | 2019-07-23 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | http://hdl.handle.net/2445/196545 | - |
dc.description.abstract | Objectives: Guidelines recommending 12-month dual antiplatelet therapy (DAPT) in patients with ST-elevation acute coronary syndrome (STEACS) undergoing percutaneous coronary intervention (PCI) were published in year 2012. We aimed to describe the influence of guideline implementation on the trend in 12-month persistence with DAPT between 2010 and 2015 and to evaluate its relationship with DAPT duration regimens recommended at discharge from PCI hospitals. Design: Observational study based on region-wide registry data linked to pharmacy billing data for DAPT follow-up. Setting: All PCI hospitals (10) belonging to the acute myocardial infarction (AMI) code network in Catalonia (Spain). Participants: 10 711 STEACS patients undergoing PCI between 2010 and 2015 were followed up. Primary and secondary outcome measures: Primary outcome was 12-month persistence with DAPT. Calendar year quarter, publication of guidelines, DAPT duration regimen recommended in the hospital discharge report, baseline patient characteristics and significant interactions were included in mixed-effects logistic regression based interrupted time-series models. Results: The proportion of patients on-DAPT at 12 months increased from 58% (56-60) in 2010 to 73% (71-75) in 2015. The rate of 12-month persistence with DAPT significantly increased after the publication of clinical guidelines with a time lag of 1 year (OR=1.20; 95% CI 1.11 to 1.30). A higher risk profile, more extensive and complex coronary disease, use of drug-eluting stents (OR=1.90; 95% CI 1.50 to 2.40) and a 12-month DAPT regimen recommendation at discharge from the PCI hospital (OR=5.76; 95% CI 3.26 to 10.2) were associated with 12-month persistence. Conclusion: Persistence with 12-month DAPT has increased since publication of clinical guidelines. Even though most patients were discharged on DAPT, only 73% with potential indication were on-DAPT 12 months after PCI. A guideline-based recommendation at PCI hospital discharge was highly associated with full persistence with DAPT. Establishing evidence-based, common prescribing criteria across hospitals in the AMI-network would favour adherence and reduce variability. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/bmjopen-2018-028114 | - |
dc.relation.ispartof | BMJ Open, 2019, vol. 9, num. 7, p. e028114 | - |
dc.relation.uri | https://doi.org/10.1136/bmjopen-2018-028114 | - |
dc.rights | cc-by (c) Ribera, Aida et al., 2019 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Malalties coronàries | - |
dc.subject.classification | Infart de miocardi | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.other | Coronary diseases | - |
dc.subject.other | Myocardial infarction | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.title | Persistence with dual antiplatelet therapy after percutaneous coronary intervention for ST-segment elevation acute coronary syndrome: a population-based cohort study in Catalonia (Spain) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695964 | - |
dc.date.updated | 2023-04-06T16:42:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31340964 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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