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Title: | Supramolecular Hydrogels Consisting of Nanofibers Increase the Bioavailability of Curcuminoids in Inflammatory Skin Diseases |
Author: | Limón Magaña, David Gil-Lianes, Pablo Rodríguez Cid, Laura Alvarado Bonilla, Helen Lissette Díaz Garrido, Natalia Mallandrich Miret, Mireia Baldomà Llavinés, Laura Calpena Campmany, Ana Cristina Domingo, Concepción Aliaga-Alcalde, Núria González Campo, Arántzazu Pérez García, M. Lluïsa (Maria Lluïsa) |
Keywords: | Agents antiinflamatoris Curcumina Antiinflammatory agents Curcumin |
Issue Date: | 1-Dec-2022 |
Abstract: | The low bioavailability of curcuminoids (CCMoids) limits their use in the treatment of inflammatory skin diseases. Our work shows that this constraint can be overcome upon their incorporation into supramolecular hydrogels assembled from a gemini-imidazolium amphiphilic gelator. Three structural CCMoid analogues were used to prepare supramolecular hydrogels, and it was observed that the concentration of both the gelator and CCMoid and the proportion of solvents influence the self-assembly process. Moreover, the mechanical properties of the nanostructured gels were studied to find the optimum gels, which were then further characterized microscopically, and their ability to release the CCMoid was evaluated. The physicochemical properties of the CCMoids play a fundamental role in the interaction with the gelator, influencing not only the gelation but also the morphology at the microscopic level, the mechanical properties, and the biopharmaceutical behavior such as the amount of CCMoid released from the gels. The nanostructured supramolecular hydrogels, which contain the CCMoids at much lower concentrations (μg/mL) in comparison to other products, promote the penetration of the CCMoids within the skin, but not their transdermal permeation, thus preventing any possible systemic effects and representing a safer option for topical administration. As a result, the CCMoid-containing hydrogels can effectively reduce skin inflammation in vivo, proving that these supramolecular systems are excellent alternatives in the treatment of inflammatory skin diseases. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acsanm.2c01482 |
It is part of: | Acs Applied Nano Materials, 2022 |
URI: | http://hdl.handle.net/2445/196600 |
Related resource: | https://doi.org/10.1021/acsanm.2c01482 |
ISSN: | 2574-0970 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Bioquímica i Fisiologia) |
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