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Title: | Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study |
Author: | Galiñanes, Manuel Casós, Kelly Blasco Lucas, Arnau Permanyer, Eduard Máñez, Rafael Le Tourneau, Thierry Barquinero, Jordi Schwartz Navarro, Simó Bottio, Tomaso Roussel, Jean Christian Fellah Hebia, Imen Sénage, Thomas Evangelista, Arturo Badano, Luigi P. Ruiz Majoral, Alejandro Galli, Cesare Padler-Karavani, Vered Soulillou, Jean-paul Vidal, Xavier Cozzi, Emanuele Costa, Cristina |
Keywords: | Estrès oxidatiu Vàlvules cardíaques Pròtesis valvulars cardíaques Oxidative stress Heart valves Heart valve prosthesis |
Issue Date: | 31-Oct-2022 |
Publisher: | MDPI AG |
Abstract: | The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunction. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/biom12111606 |
It is part of: | Biomolecules, 2022, vol. 12, num. 11, p. 1606 |
URI: | http://hdl.handle.net/2445/196613 |
Related resource: | https://doi.org/10.3390/biom12111606 |
ISSN: | 2218-273X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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biomolecules-12-01606-v3.pdf | 6.01 MB | Adobe PDF | View/Open |
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