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Title: The role of lipids in cancer progression and metastasis
Author: Martín Pérez, Miguel
Urdiroz Urricelqui, Uxue
Bigas, Claudia
Aznar Benitah, Salvador
Keywords: Metabolisme dels lípids
Tractament adjuvant del càncer
Lipid metabolism
Adjuvant treatment of cancer
Issue Date: 1-Nov-2022
Publisher: Cell Press
Abstract: Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.
Note: Versió postprint del document publicat a:
It is part of: Cell Metabolism, 2022, vol. 34, num. 11, p. 1675-1699
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ISSN: 1550-4131
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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