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http://hdl.handle.net/2445/197012
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DC Field | Value | Language |
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dc.contributor.author | Humbert, Marc | - |
dc.contributor.author | Simonneau, Gérald | - |
dc.contributor.author | Pittrow, David | - |
dc.contributor.author | Delcroix, Marion | - |
dc.contributor.author | Pepke-Zaba, Joanna | - |
dc.contributor.author | Langleben, David | - |
dc.contributor.author | Mielniczuk, Lisa M. | - |
dc.contributor.author | Escribano Subias, Pilar | - |
dc.contributor.author | Snijder, Repke J. | - |
dc.contributor.author | Barberà i Mir, Joan Albert | - |
dc.contributor.author | Klotsche, Jens | - |
dc.contributor.author | Meier, Christian | - |
dc.contributor.author | Hoeper, Marius M | - |
dc.date.accessioned | 2023-04-21T15:36:30Z | - |
dc.date.available | 2023-04-21T15:36:30Z | - |
dc.date.issued | 2022-02-11 | - |
dc.identifier.issn | 1053-2498 | - |
dc.identifier.uri | http://hdl.handle.net/2445/197012 | - |
dc.description.abstract | EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study in patients with pulmonary hypertension treated with riociguat. Patients were followed for 1-4 years, and the primary outcomes were adverse events (AEs) and serious AEs (SAEs), including embolic/thrombotic and hemorrhagic events. Here we report data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) receiving a vitamin K antagonist (VKA; n = 683) or a non-vitamin K antagonist oral anticoagulant (NOAC; n = 198) at baseline. AEs and SAEs were reported in 438 patients (64.1%) and 257 patients (37.6%), respectively, in the VKA group, and in 135 patients (68.2%) and 74 patients (37.4%) in the NOAC group. Exposure-adjusted hemorrhagic event rates were similar in the two groups, while exposure-adjusted embolic and/or thrombotic event rates were higher in the NOAC group, although the numbers of events were small. Further studies are required to determine the long-term effects of anticoagulation strategies in CTEPH. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.healun.2022.02.002 | - |
dc.relation.ispartof | Journal of Heart and Lung Transplantation, 2022, vol. 41, num. 6, p. 716-721 | - |
dc.relation.uri | https://doi.org/10.1016/j.healun.2022.02.002 | - |
dc.rights | cc-by-nc-nd (c) Humbert, Marc et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Hipertensió pulmonar | - |
dc.subject.classification | Malalties cròniques | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.classification | Efectes secundaris dels medicaments | - |
dc.subject.classification | Vitamines K | - |
dc.subject.other | Pulmonary hypertension | - |
dc.subject.other | Chronic diseases | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.subject.other | Drug side effects | - |
dc.subject.other | Vitamin K | - |
dc.title | Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 733409 | - |
dc.date.updated | 2023-04-21T15:36:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35305871 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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733409.pdf | 270.4 kB | Adobe PDF | View/Open |
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