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DC Field | Value | Language |
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dc.contributor.author | Sans de San Nicolàs, Lídia | - |
dc.contributor.author | Figueras Nart, Ignasi | - |
dc.contributor.author | García Jiménez, Irene | - |
dc.contributor.author | Bonfill Ortí, Montserrat | - |
dc.contributor.author | Guilabert, Antonio | - |
dc.contributor.author | Curto Barredo, Laia | - |
dc.contributor.author | Bertolín Colilla, Marta | - |
dc.contributor.author | Ferran, Marta | - |
dc.contributor.author | Serra Baldrich, Esther | - |
dc.contributor.author | Pujol, Ramon M. | - |
dc.contributor.author | Santamaria Babí, Luis F. | - |
dc.date.accessioned | 2023-04-25T06:55:18Z | - |
dc.date.available | 2023-04-25T06:55:18Z | - |
dc.date.issued | 2023-03-13 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/197180 | - |
dc.description.abstract | Background:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. ResultsHDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)(+) T-cell subset. ConclusionIgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1124018 | - |
dc.relation.ispartof | Frontiers in Immunology, 2023, vol. 14, num. 1124018 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2023.1124018 | - |
dc.rights | cc by (c) Sans de San Nicolàs, Lídia et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Dermatitis atòpica | - |
dc.subject.classification | Al·lèrgens | - |
dc.subject.classification | Citocines | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.other | Atopic dermatitis | - |
dc.subject.other | Allergens | - |
dc.subject.other | Cytokines | - |
dc.subject.other | T cells | - |
dc.title | Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-04-21T13:51:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36993985 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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fimmu-14-1124018.pdf | 2.92 MB | Adobe PDF | View/Open |
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