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Title: | Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables |
Author: | Solé Morata, Neus Baenas, Isabel Etxandi, Mikel Granero, Roser Gené, Manel Barrot i Feixat, Carme Gómez-Peña, Mónica Moragas, Laura Ramoz, Nicolás Gorwood, Philip Fernández Aranda, Fernando Jiménez-Murcia, Susana |
Keywords: | Joc compulsiu Psicopatologia Personalitat Genètica Compulsive gambling Pathological psychology Personality Genetics |
Issue Date: | 1-Jan-2023 |
Publisher: | MDPI |
Abstract: | Gambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD severity by considering the direct and mediational relationship between different variables including genetic, psychological, socio-demographic, and clinical factors. To do so, we used genetic variants that were significantly associated with an increased risk for GD and evaluated its relationship with GD severity through pathway analysis. We found that the interaction between these genetic variants and other different biopsychological features predicted a higher severity of GD. On the one hand, the presence of haplotype block 2, interrelated with haplotype block 3, was linked to a more dysfunctional personality profile and a worse psychopathological state, which, in turn, had a direct link with GD severity. On the other hand, having rs3763614 predicted higher general psychopathology and therefore, higher GD severity. The current study described the presence of complex interactions between biopsychosocial variables previously associated with the etiopathogenesis and severity of GD, while also supporting the involvement of genetic variants from the NTF family. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu15020418 |
It is part of: | Nutrients, 2023, vol. 15, num. 2 |
URI: | http://hdl.handle.net/2445/197203 |
Related resource: | https://doi.org/10.3390/nu15020418 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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