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Title: Nanoscale ligand density modulates gap junction intercellular communication of cell condensates during chondrogenesis
Author: Casanellas, Ignasi
Lagunas, Anna
Vida, Yolanda
Pérez Inestrosa, Ezequiel
Rodríguez Pereira, Cristina
Magalhaes, Joana
Andrades, José A.
Becerra, José
Samitier i Martí, Josep
Keywords: Condrogènesi
Materials nanoestructurats
Enginyeria de teixits
Nanostructured materials
Tissue engineering
Issue Date: 1-Jun-2022
Publisher: Future Medicine
Abstract: Aim: To unveil the influence of cell-matrix adhesions in the establishment of gap junction intercellular communication (GJIC) during cell condensation in chondrogenesis. Materials & methods: Previously developed nanopatterns of the cell adhesive ligand arginine-glycine-aspartic acid were used as cell culture substrates to control cell adhesion at the nanoscale. In vitro chondrogenesis of mesenchymal stem cells was conducted on the nanopatterns. Cohesion and GJIC were evaluated in cell condensates. Results: Mechanical stability and GJIC are enhanced by a nanopattern configuration in which 90% of the surface area presents adhesion sites separated less than 70 nm, thus providing an onset for cell signaling. Conclusion: Cell-matrix adhesions regulate GJIC of mesenchymal cell condensates during in vitro chondrogenesis from a threshold configuration at the nanoscale.
Note: Versió postprint del document publicat a:
It is part of: Nanomedicine, 2022, vol. 17, num. 11, p. 775-791
Related resource:
ISSN: 1743-5889
Appears in Collections:Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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