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|Title:||Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts|
|Author:||Rothwell, Joseph A.|
Cross, Amanda J.
Boutron-Ruault, Marie Christine
Dahm, Christina C.
Nøst, Therese Haugdahl
Sandanger, Torkjel M.
Tsilidis, Kostas K.
Schulze, Matthias B.
Guelpen, Bethany van
Sánchez, Maria José
Derksen, Jeroen W. G.
Colorado Yohar, Sandra
Bueno de Mesquita, Bas
Eriksen, Anne Kirstine
Gunter, Marc J.
|Publisher:||Springer Science and Business Media LLC|
|Abstract:||BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.MethodsConcentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.ResultsHistidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.ConclusionsHigher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1186/s12916-023-02739-4|
|It is part of:||BMC Medicine, 2023, vol. 21, num. 1|
|Appears in Collections:||Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))|
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