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Title: New Procedure to Maintain Fecal Microbiota in a Dry Matrix Ready to Encapsulate
Author: Aira Gómez, Andrea
Rubio, Elisa
Vergara Gómez, Andrea
Casals Pascual, Climent
Rico, Verónica
Suñé i Negre, Josep M. (Josep Maria)
Soriano, Álex
Keywords: Microbiota intestinal
Malalties bacterianes
Gastrointestinal microbiome
Bacterial diseases
Issue Date: 2022
Publisher: Frontiers Media
Abstract: Fecal microbiota transplantation (FMT) is one of the recommended treatments for recurrent Clostridioides difficile infection, but endoscopy and available oral formulations still have several limitations in their preparation, storage, and administration. The need for a viable oral formulation that facilitates the implementation of this highly effective therapy in different settings has led us to test the microcrystalline cellulose particles as an adsorbent of concentrated filtered fresh feces in comparison to lyophilized feces. This free-flowing material can provide protection to bacteria and results in a dried product able to maintain the viability of the microbiota for a long time. Adsorbate formulation showed a stabilizing effect in gut microbiota, maintaining bacteria viability and preserving its diversity, and is a competitive option for lyophilized capsules. Keywords: FMT; adsorbate; capsules; gut microbiota; lyophilization.
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It is part of: Frontiers in Cellular and Infection Microbiology, 2022, vol. 12, num. 1, p. 9
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ISSN: 2235-2988
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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