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http://hdl.handle.net/2445/197930
Title: | Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication |
Author: | Garcia Vidal, Carolina Iglesias, María Puerta Alcalde, Pedro Mas, Vicente Cuesta Chasco, Genoveva García Pouton, Nicole Varona, Sarai Pozo, Francisco Vázquez Morón, Sonia Marcos, Ma. Angeles Soriano Viladomiu, Alex Casas Flecha, Inmaculada HEMATOCOVID19-Researchers Group |
Keywords: | COVID-19 SARS-CoV-2 Medicaments antivírics Hematologia Immunosupressió Mutació (Biologia) COVID-19 SARS-CoV-2 Antiviral agents Hematology Immunosuppression Mutation (Biology) |
Issue Date: | 1-Mar-2022 |
Publisher: | Frontiers Media |
Abstract: | We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2022.826883 |
It is part of: | Frontiers in Microbiology, 2022, vol. 13, p. 826883 |
URI: | http://hdl.handle.net/2445/197930 |
Related resource: | https://doi.org/10.3389/fmicb.2022.826883 |
ISSN: | 1664-302X |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (ISGlobal) |
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