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http://hdl.handle.net/2445/198246
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DC Field | Value | Language |
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dc.contributor.author | Peris-Martínez, Cristina | - |
dc.contributor.author | Piá-Ludeña, Jose Vicente | - |
dc.contributor.author | Rog-Revert, María José | - |
dc.contributor.author | Fernández-López, Ester | - |
dc.contributor.author | Domingo i Pedrol, Joan Carles | - |
dc.date.accessioned | 2023-05-19T16:30:38Z | - |
dc.date.available | 2023-05-19T16:30:38Z | - |
dc.date.issued | 2023-03-06 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/198246 | - |
dc.description.abstract | A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I-III (Amsler-Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu15051300 | - |
dc.relation.ispartof | Nutrients, 2023, vol. 15, num. 5, p. 1300 | - |
dc.relation.uri | https://doi.org/10.3390/nu15051300 | - |
dc.rights | cc-by (c) Peris-Martínez, Cristina et al., 2023 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.classification | Àcids grassos omega-3 | - |
dc.subject.other | Oxidative stress | - |
dc.subject.other | Omega-3 fatty acids | - |
dc.title | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 732763 | - |
dc.date.updated | 2023-05-19T16:30:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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732763.pdf | 669.21 kB | Adobe PDF | View/Open |
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