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Title: | BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitorsBRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors |
Author: | Veeck, Jürgen Ropero, Santiago Setién, Fernando Gonzalez-Suarez, Eva Osorio, Ana Benitez, Javier Herman, James G. Esteller, Manel |
Keywords: | Proteïnes supressores de tumors ADN Malalties de l'ovari Genètica Tumor suppressor protein DNA Ovary diseases Genetics |
Issue Date: | 10-Oct-2010 |
Publisher: | American Society of Clinical Oncology |
Abstract: | Recently, Fong et al reported the antitumor activity of the poly(adenosine diphosphate)-ribose polymerase (PARP) inhibitor olaparib (AZD2281; KU-0059436) in patients with BRCA1/BRCA2 germline mutated ovarian cancer. Female BRCA1 and BRCA2 mutation carriers have a significantly elevated lifetime risk of breast and ovarian cancer. BRCA1 and BRCA2 proteins play major roles in DNA double-strand break repair through homologous recombination, and inhibition of DNA single-strand break repair leads to the accumulation of double-strand breaks. These potentially lethal events in homologous recombination-deficient cells could be exploited for therapeutic purposes. The PARP-1 protein is essential for single-strand break repair, and inhibition of PARP leads to persistence of DNA lesions normally repaired by homologous recombination. |
Note: | Reproducció del document publicat a: https://doi.org/10.1200/JCO.2010.30.1010 |
It is part of: | Journal of Clinical Oncology, 2010, vol. 28, num. 29, p. e563-e564 |
URI: | http://hdl.handle.net/2445/198525 |
Related resource: | https://doi.org/10.1200/JCO.2010.30.1010 |
ISSN: | 0732-183X |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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