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http://hdl.handle.net/2445/198615
Title: | Time to sputum conversion in patients with pulmonary tuberculosis: A score to estimate the infectious period |
Author: | Ramirez Hidalgo, Maria Trujillano Cabello, Javier Espluges Vidal, Adrià Reñé Reñé, Mercé Santín Cerezales, Miguel Sánchez Montalvá, Adrián Bernet Sánchez, Albert Gros Navés, Laura Falguera, Miquel |
Keywords: | Tuberculosi Esput Factors de risc en les malalties Tuberculosis Sputum Risk factors in diseases |
Issue Date: | 1-May-2023 |
Publisher: | Elsevier BV |
Abstract: | Introduction: Patients with pulmonary tuberculosis (PTB) disease and positive sputum cultures are the main source of infection. Culture conversion time is inconsistent and defining the length of respiratory isolation is challenging. The objective of this study is to develop a score to predict the length of isolation period.Methods: A retrospective study was carried out to evaluated risk factors associated with persistent positive sputum cultures after 4 weeks of treatment in 229 patients with PTB. A multivariable logistic regression model was used to determinate predictors for positive culture and a scoring system was created based on the coefficients of the final model.Results: Sputum culture was persistently positive in 40.6%. Fever at consultation (1.87, 95% CI:1.02-3.41), smoking (2.44, 95% CI:1.36-4.37), >2 affected lung lobes (1.95, 95% CI:1.08-3.54), and neutrophil-to-lymphocyte ratio > 3.5 (2.22, 95% CI:1.24-3.99), were significantly associated with delayed culture conver-sion. Therefore, we assembled a severity score that achieved an area under the curve of 0.71 (95% CI:0.64-0.78).Conclusions: In patients with smear positive PTB, a score with clinical, radiological and analytical parameters can be used as a supplemental tool to assist clinical decisions in isolation period. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jctube.2023.100361 |
It is part of: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2023, vol. 31, p. 100361 |
URI: | http://hdl.handle.net/2445/198615 |
Related resource: | https://doi.org/10.1016/j.jctube.2023.100361 |
ISSN: | 2405-5794 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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