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http://hdl.handle.net/2445/199201
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DC Field | Value | Language |
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dc.contributor.author | Cantón, Rafael | - |
dc.contributor.author | Loza, Elena | - |
dc.contributor.author | Aznar, Javier | - |
dc.contributor.author | Barrón-Adúriz, Rubén | - |
dc.contributor.author | Calvo, Jorge | - |
dc.contributor.author | Castillo, F. Javier | - |
dc.contributor.author | Cercenado, Emilia | - |
dc.contributor.author | Cisterna, Ramón | - |
dc.contributor.author | González Romo, Fernando | - |
dc.contributor.author | López Hontangas, Jose Luis | - |
dc.contributor.author | Suárez Barrenechea, Ana Isabel | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Molloy, Brian | - |
dc.contributor.author | López Mendoza, Diego | - |
dc.contributor.author | SMART-SPAIN Working Group | - |
dc.contributor.author | Domínguez Luzón, Ma. Ángeles (María Ángeles) | - |
dc.date.accessioned | 2023-06-13T16:50:33Z | - |
dc.date.available | 2023-06-13T16:50:33Z | - |
dc.date.issued | 2018-04-01 | - |
dc.identifier.issn | 0214-3429 | - |
dc.identifier.uri | http://hdl.handle.net/2445/199201 | - |
dc.description.abstract | Objective: The SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study monitors antimicrobial susceptibility and extended spectrum β-lactamases (ESBLs) in Gram-negative bacilli recovered from intra-abdominal infections (IAI). Methods: Antimicrobial susceptibility of 5,343 isolates from IAI recovered in 11 centres during the 2011-2015 SMART-Spain program was analysed by standard microdilution (EUCAST criteria) and compared with that from 2002-2010. ESBLs were phenotypically detected. Results: Escherichia coli, the most common isolate, significantly decreased in community acquired IAI (60.9% 2002-2010 vs. 56.1% 2011-2015, P=0.0003). It was followed in prevalence by Klebsiella pneumoniae that increased both in the community (8.9% vs. 10.8%, P=0.016) and nosocomial (9.2% vs. 10.8%, P=0.029) IAI and P. aeruginosa, which significantly increased in community acquired IAI (5.6% vs. 8.0%, P=0.0003). ESBLs were more prevalent in K. pneumoniae (16.3%) than in E. coli (9.5%) of nosocomial origin and were more frequently isolated from elderly patients (>60 years). Considering all Enterobacteriaceae, ertapenem (92.3-100%) and amikacin (95.5%-100%) were the most active antimicrobials. Ertapenem activity, unlike amoxicillin-clavulanate or piperacillin-tazobactam, remained virtually unchanged in ESBL (100%) and non-ESBL (98.8%) E. coli producers. Its activity decreased in ESBL-K. pneumoniae (74.7%) but was higher than that of amoxicillin-clavulanate (14.0%) and piperacillin-tazobactam (24.0%). Interestingly, ertapenem susceptibility was maintained in >60% of ESBL isolates that were resistant to amoxicillin-clavulanate, piperacillin-tazobactam or fluoroquinolones. Conclusions: SMART-Spain results support current guidelines which include ertapenem as empiric treatment in mild-moderate community-acquired IAI, particularly with ESBL producers. These recommendations will need to be updated with the recently introduction of new antimicrobials. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Sociedad Española de Quimioterapia | - |
dc.relation.isformatof | Reproducció del document publicat a: https://seq.es/abstract/rev-esp-quimioter-2018-march-12-2/ | - |
dc.relation.ispartof | Revista Espanola de Quimioterapia, 2018, vol. 31, num. 2, p. 136-145 | - |
dc.rights | (c) Sociedad Española de Quimioterapia, 2018 | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Medicaments antibacterians | - |
dc.subject.classification | Infeccions per escheríchia coli | - |
dc.subject.classification | Bacteris gramnegatius | - |
dc.subject.other | Antibacterial agents | - |
dc.subject.other | Escherichia coli infections | - |
dc.subject.other | Gram-negative bacteria | - |
dc.title | Antimicrobial susceptibility trends and evolution of isolates with extended spectrum beta-lactamases among Gram-negative organisms recovered during the SMART study in Spain (2011-2015) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711307 | - |
dc.date.updated | 2023-06-13T16:50:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29532655 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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711307.pdf | 792.83 kB | Adobe PDF | View/Open |
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