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http://hdl.handle.net/2445/199582
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DC Field | Value | Language |
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dc.contributor.author | Bantulà, Marina | - |
dc.contributor.author | Tubita, Valeria | - |
dc.contributor.author | Roca Ferrer, Jordi | - |
dc.contributor.author | Mullol i Miret, Joaquim | - |
dc.contributor.author | Valero, Antonio | - |
dc.contributor.author | Bobolea, Irina | - |
dc.contributor.author | Pascal i Capdevila, Mariona | - |
dc.contributor.author | Hollanda Ramírez, Ana M. de | - |
dc.contributor.author | Vidal, Josep | - |
dc.contributor.author | Picado Vallés, César | - |
dc.contributor.author | Arismendi, Ebymar | - |
dc.date.accessioned | 2023-06-21T09:57:40Z | - |
dc.date.available | 2023-06-21T09:57:40Z | - |
dc.date.issued | 2022-06-29 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/199582 | - |
dc.description.abstract | Obesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and-independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm11133782 | - |
dc.relation.ispartof | Journal Of Clinical Medicine, 2022, vol. 11, num. 13 | - |
dc.relation.uri | https://doi.org/10.3390/jcm11133782 | - |
dc.rights | cc by (c) Bantulà, Marina et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Asma | - |
dc.subject.classification | Obesitat | - |
dc.subject.other | Asthma | - |
dc.subject.other | Obesity | - |
dc.title | Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-20T10:44:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9330620 | - |
dc.identifier.pmid | 35807067 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Differences in Inflammatory Cytokine Profile in_ClinicalMedicine.pdf | 1.05 MB | Adobe PDF | View/Open |
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