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dc.contributor.authorBantulà, Marina-
dc.contributor.authorTubita, Valeria-
dc.contributor.authorRoca Ferrer, Jordi-
dc.contributor.authorMullol i Miret, Joaquim-
dc.contributor.authorValero, Antonio-
dc.contributor.authorBobolea, Irina-
dc.contributor.authorPascal i Capdevila, Mariona-
dc.contributor.authorHollanda Ramírez, Ana M. de-
dc.contributor.authorVidal, Josep-
dc.contributor.authorPicado Vallés, César-
dc.contributor.authorArismendi, Ebymar-
dc.description.abstractObesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and-independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.format.extent19 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofJournal Of Clinical Medicine, 2022, vol. 11, num. 13-
dc.rightscc by (c) Bantulà, Marina et al, 2022-
dc.sourceArticles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)-
dc.titleDifferences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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