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http://hdl.handle.net/2445/199761
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DC Field | Value | Language |
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dc.contributor.author | Llorente, Xavier | - |
dc.contributor.author | Esteruelas Navarro, Gerard | - |
dc.contributor.author | Bonilla, Lorena | - |
dc.contributor.author | Garnica Agudelo, Mariana | - |
dc.contributor.author | Filgaira, Ingrid | - |
dc.contributor.author | Lopez-Ramajo, Daniel | - |
dc.contributor.author | Gong, Ruoyi C. | - |
dc.contributor.author | Soler Prat, Concepció | - |
dc.contributor.author | Espina García, Marta | - |
dc.contributor.author | García López, María Luisa | - |
dc.contributor.author | Manils Pacheco, Joan | - |
dc.contributor.author | Pujol Cubells, Montserrat | - |
dc.contributor.author | Sánchez-López, E. (Elena) | - |
dc.date.accessioned | 2023-06-23T10:23:24Z | - |
dc.date.available | 2023-06-23T10:23:24Z | - |
dc.date.issued | 2023-04-29 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/199761 | - |
dc.description.abstract | Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment efficacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms24098053 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2023, vol. 24, p. 8053 | - |
dc.relation.uri | https://doi.org/10.3390/ijms24098053 | - |
dc.rights | cc-by (c) Llorente, Xavier et al., 2023 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.classification | Malalties de la pell | - |
dc.subject.other | Nanoparticles | - |
dc.subject.other | Skin diseases | - |
dc.title | Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 733570 | - |
dc.date.updated | 2023-06-23T10:23:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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733570.pdf | 3.34 MB | Adobe PDF | View/Open |
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