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http://hdl.handle.net/2445/200286
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DC Field | Value | Language |
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dc.contributor.author | Solá Castrillo, Paloma | - |
dc.contributor.author | Mereu, Elisabetta | - |
dc.contributor.author | Bonjoch, Júlia | - |
dc.contributor.author | Casado Peláez, Marta | - |
dc.contributor.author | Prats, Neus | - |
dc.contributor.author | Aguilera, Mònica | - |
dc.contributor.author | Reina, Oscar | - |
dc.contributor.author | Blanco, Enrique | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Croce, Luciano Di | - |
dc.contributor.author | Heyn, Holger | - |
dc.contributor.author | Solanas Fuster, Guiomar | - |
dc.contributor.author | Benitah, Salvador A. | - |
dc.date.accessioned | 2023-07-04T11:09:10Z | - |
dc.date.available | 2023-07-04T11:09:10Z | - |
dc.date.issued | 2023-06-08 | - |
dc.identifier.issn | 2662-8465 | - |
dc.identifier.uri | http://hdl.handle.net/2445/200286 | - |
dc.description.abstract | Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored by proinflammatory microenvironments that drive pleotropic changes. The nature of these age-associated inflammatory cues, or how they affect tissue aging, is unknown. Based on single-cell RNA sequencing of the dermal compartment of mouse skin, we show a skew towards an IL-17-expressing phenotype of T helper cells, γδ T cells and innate lymphoid cells in aged skin. Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age-related traits. Mechanistically, aberrant IL-17 signals through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state. Our results indicate that aged skin shows signs of chronic inflammation and that increased IL-17 signaling could be targeted to prevent age-associated skin ailments.© 2023. The Author(s). | - |
dc.format.extent | 34 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s43587-023-00431-z | - |
dc.relation.ispartof | Nature Aging, 2023, vol. 3, num. 6, p. 688-704 | - |
dc.relation.uri | https://doi.org/10.1038/s43587-023-00431-z | - |
dc.rights | cc by (c) Solá Castrillo, Paloma et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Immunitat | - |
dc.subject.classification | Pell | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | Immunity | - |
dc.subject.other | Skin | - |
dc.subject.other | Aging | - |
dc.title | Targeting lymphoid-derived IL-17 signaling to delay skin aging | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-30T09:45:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6597148 | - |
dc.identifier.pmid | 37291218 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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Solà_Aznar_NatAging_2023.pdf | 9.27 MB | Adobe PDF | View/Open |
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