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Title: Creatine Kinase Elevation in Autosomal Dominant Polycystic Kidney Disease Patients on Tolvaptan Treatment
Author: Rodríguez Espinosa, Diana
Broseta, José Jesús
Bastida, Carla
Álvarez Mora, María Isabel
Nicolau, Carlos
Álvarez, Cristina
Agraz, Irene
Sánchez Baya, Maya
Furlano, Monica
Ruiz, César
Quintana Porras, Luis F.
Piñeiro, Gaston Julio
Poch López de Briñas, Esteban
Torra, Roser
Blasco Pelicano, Miquel
Keywords: Creatina quinasa
Malalties del ronyó
Efectes secundaris dels medicaments
Creatine kinase
Kidney diseases
Drug side effects
Cysts (Pathology)
Issue Date: 9-Sep-2022
Publisher: Karger AG
Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of end-stage kidney disease. Currently, tolvaptan is the only treatment that has proven to delay disease progression. The most notable side effect of this therapy is drug-induced liver injury; however, recently, there have been two reports of creatine kinase (CK) elevation in ADPKD patients on tolvaptan treatment. We set out to monitor and determine the actual incidence of CK elevation and evaluate its potential association with other clinical factors. Methods: This is an observational retrospective multicenter study performed in rapidly progressive ADPKD patients on tolvaptan treatment from Barcelona, Spain. Laboratory tests, demographics, treatment dose, and reported symptoms were collected from October 2018 to March 2021. Results: Ninety-five patients initiated tolvaptan treatment during follow-up. The medication had to be discontinued in 31 (32.6%) patients, primarily due to aquaretic effects (12.6%), elevated liver enzymes (8.4%), and symptomatic or persistently elevated CK levels (3.2%). Moreover, a total of 27 (28.4%) patients had elevated CK levels, with most of them being either transient (12.6%), mild and asymptomatic (4.2%), or resolved after dose reduction (3.2%) or temporary discontinuation (2.1%). Conclusion: We pre-sent the largest cohort that has monitored CK levels in a real-life setting, finding them elevated in 28.4% of patients. More research and monitoring will help us understand the clinical implications and the pathophysiological mechanism of CK elevation in this population.
Note: Reproducció del document publicat a:
It is part of: Nephron, 2022, vol. 147, num. 3-4, p. 152-157
Related resource:
ISSN: 1660-8151
Appears in Collections:Articles publicats en revistes (Medicina)

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